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  • NIH VideoCast - At the Crossroads of Social Media and Clinical Trials: A Workshop on the Future of Clinician, Patient and Community Engagement (Day 2)
    • - Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis, NCI (2018/06/13)
    • - Category : Conferences
    In the modern age of digital media, a large majority of adults now use online resources to obtain health information and connect with clinicians, other patients and patient-centered communities. Consequently, there is an opportunity to improve patient engagement and education surrounding clinical trials through the use of social media platforms. The primary objective of NCI???s ???At the Crossroads of Social Media and Clinical Trials: A Workshop on the Future of Clinician, Patient and Community Engagement??? is to convene experts in clinical trials, social media, communications as well as patients and patient advocates in a highly interactive setting to learn, network, and discuss best practices to successfully engage and educate the public and health care providers about clinical trials using evidence-based social media strategies. Through this workshop, we hope to build trust and improve informed decision-making about clinical trials.

    The workshop will be composed of six sessions over two days.

    ??? Day 1: a) Provide an overview of the current role and potential value of social media in clinical trials b) Offer perspectives and experiences from successful online patient and clinician communities c) Explore potential partnership opportunities to enhance social media

    ??? Day 2: a) Discuss social media tools and metrics to measure and evaluate effectiveness of social media strategies b) Discuss regulatory considerations around the use of social media in clinical trials c) Future considerations for moving forward to improve outreach around clinical trials via social media

    A breakout session is planned for the second day to encourage free exchange of ideas and ???lessons learned??? as well as identify opportunities for next steps using knowledge gained. At the end of the workshop we hope to have synthesized new ideas and facilitated a new cross-disciplinary network from which the NCI can draw on to support its clinical trials outreach efforts. After the workshop, we hope to develop a ???social media best practices toolkit??? that includes a combination of outreach strategies, resources, and evaluation metrics to support the clinical trials community in order increase their presence and engagement with patient and clinician communities.
  • NIH VideoCast - Memory and Integration of Face and Vocal Information in the Primate Prefrontal Cortex
    • - Liz Romanski, Ph.D., University of Rochester Medical Center (2018/06/13)
    • - Category : Neuroscience
    NIH Neuroscience Series Seminar

    While auditory and visual information are combined in many sites of the human brain, the combining of face and vocal information for effective communication has been shown to occur in specialized regions of the temporal and frontal lobes. Work in Dr. Romanski???s laboratory is focused on how the ventral prefrontal cortex represents high level auditory information and the neuronal mechanisms which underlie integration of complex auditory and visual information, primarily face and vocal information during communication. Studies in their laboratory have shown that neurons within specific regions of the ventral prefrontal cortex are robustly responsive to complex sounds including species-specific vocalizations, while previous studies have shown that adjacent ventral prefrontal regions are selectively responsive to faces. They have shown that neurons within ventral prefrontal cortex are multisensory and respond to both faces and to the corresponding vocalizations. They are also interested in the factors that affect the integration of dynamic faces and vocalizations in the frontal lobe including temporal coincidence, stimulus congruence, as well as the emotional expression conveyed in the face-vocalization and the identity of the speaker. Collaborations with University of Rochester faculty are aimed at characterizing sensory integration deficits in children with autism and the role the frontal lobe may play in autism spectrum disorders. Further analysis of the neural mechanisms which support face and voice integration in non-human primates may help them to understand the mechanisms underlying social communication and social cognition.

    For more information go to https://neuroscience.nih.gov/neuroseries/home.aspx
  • NIH VideoCast - Biowulf Seminar Series - Bioinformatics Methods for Immunogen Conformational Stabilization and Antibody Resistance Prediction
    • - Gwo-Yu Chuang, Ph.D., VRC, NIAID, NIH (2018/06/13)
    • - Category : Special
    NIH Biowulf Seminar

    Viral surface antigens can be used as subunit vaccines and are often primary targets for neutralizing antibodies. However, for some viral antigens such as HIV-1, conformational flexibility can prevent elicitation of an effective neutralization response, and high sequence diversity and mutation rates can reduce the efficacy of antibody treatment. Here, I am going to discuss two topics: (1) immunogen conformational stabilization and (2) antibody resistance prediction, while demonstrating how both can be performed computationally. With respect to immunogen conformational stabilization, I will first illustrate different computational methods that can perform this task, and then describe an automated pipeline, CRISPRo, that design proline mutations for protein conformational stabilization. In regards to antibody resistance prediction, I will present bNAb-ReP, a gradient boosting machine learning algorithm developed to predict HIV-1 antibody resistance with high accuracy for both training set data and viral sequences obtained from clinical trials. The tools we developed here can facilitate the discovery of effective subunit vaccines and will inform clinical decisions of antibody usage when treating HIV positive patients. For more information go to https://hpc.nih.gov/training
  • NIH VideoCast - mHealth Technology Showcase
    • - Center of Excellence for Mobile Sensor Data-to-Knowledge (2018/06/12)
    • - Category : Conferences
    Mobile health (mHealth) provides unprecedented opportunities to measure dynamic changes in health state and the key physical, biological, behavioral, social, and environmental factors that contribute to health and disease risk. In the last decade a significant number of mHealth technologies have been developed and applied to advance health research. They include wearable and mobile sensors for data collection; discovery and validation of novel mHealth biomarkers; software platforms for large-scale participant enrollment and data collection; big data software for data analysis, visualization, and discovery, and mobile apps for self-monitoring and intervention.

    An mHealth Technology Showcase will bring together technology developers and health researchers on the National Institutes of Health (NIH) campus in Bethesda, Maryland. The goal for the meeting is to discuss how these communities can work together to improve the specificity, reliability, and validity of health indicators identified from data collected from wearable and mobile sensors, in the context of rapidly evolving and increasingly complex and diverse technologies.

    For more information go to https://mhealth.md2k.org/2018-tech-showcase-home
  • NIH VideoCast - NICHD Advisory Council Meeting - June 2018
    • - NICHD, NIH (2018/06/09)
    • - Category : National Institute of Child Health and Human Development
    To help achieve the goals of the Institute, the NACHHD Council is charged with advising, consulting with, and making recommendations to the NICHD director on matters relating to the research and research support activities and functions of the Institute.
  • NIH VideoCast - At the Crossroads of Social Media and Clinical Trials: A Workshop on the Future of Clinician, Patient and Community Engagement (Day 1)
    • - Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis, NCI, NIH (2018/06/09)
    • - Category : Conferences
    In the modern age of digital media, a large majority of adults now use online resources to obtain health information and connect with clinicians, other patients and patient-centered communities. Consequently, there is an opportunity to improve patient engagement and education surrounding clinical trials through the use of social media platforms. The primary objective of NCI???s ???At the Crossroads of Social Media and Clinical Trials: A Workshop on the Future of Clinician, Patient and Community Engagement??? is to convene experts in clinical trials, social media, communications as well as patients and patient advocates in a highly interactive setting to learn, network, and discuss best practices to successfully engage and educate the public and health care providers about clinical trials using evidence-based social media strategies. Through this workshop, we hope to build trust and improve informed decision-making about clinical trials.

    The workshop will be composed of six sessions over two days.

    ??? Day 1: a) Provide an overview of the current role and potential value of social media in clinical trials b) Offer perspectives and experiences from successful online patient and clinician communities c) Explore potential partnership opportunities to enhance social media

    ??? Day 2: a) Discuss social media tools and metrics to measure and evaluate effectiveness of social media strategies b) Discuss regulatory considerations around the use of social media in clinical trials c) Future considerations for moving forward to improve outreach around clinical trials via social media

    A breakout session is planned for the second day to encourage free exchange of ideas and ???lessons learned??? as well as identify opportunities for next steps using knowledge gained. At the end of the workshop we hope to have synthesized new ideas and facilitated a new cross-disciplinary network from which the NCI can draw on to support its clinical trials outreach efforts. After the workshop, we hope to develop a ???social media best practices toolkit??? that includes a combination of outreach strategies, resources, and evaluation metrics to support the clinical trials community in order increase their presence and engagement with patient and clinician communities.
  • NIH VideoCast - ORWH Women`s Health Seminar Series: Sex and the Head-Heart Connection
    • - Dr. Nakela Cook, NHLBI, NIH; Dr. Jill Goldstein, Massachusetts General Hospital/Harvard Medical School; Dr. Ana Langer, Harvard School of Public Health; Dr. Virginia Miller, Mayo Clinic (2018/06/09)
    • - Category : Women`s Health
    ORWH Women`s Health Seminar Series

    This presentation is designed to raise visibility of heart/brain co-morbidities seen through the lens of sex differences.

    For more information go to https://orwh.od.nih.gov/seminar-series/register
  • NIH VideoCast - 13th Annual Pain Consortium Symposium: At the Intersection of Pain Management and the Opioid Crisis (Day 2)
    • - NIH (2018/06/08)
    • - Category : Conferences
    The NIH Pain Consortium sponsors an annual symposium on a significant topic relevant to pain. This symposium features NIH supported researchers whose work has made an important contribution to pain research. In addition to speakers and panel sessions, there is a poster session featuring early career investigators. Researchers with the best abstracts are selected to give an oral presentation, and the best presenter receives the Mitchell Max Award for Best Poster.

    For more information go to https://painconsortium.nih.gov/Meetings_Events/Annual_Symposium
  • NIH VideoCast - National Advisory Council for Complementary and Integrative Health (NACCIH) ??? June 2018
    • - NCCIH, NIH (2018/06/08)
    • - Category : Advisory Board Meetings and Workshops
    This is the Open Session of the 66th meeting of the National Advisory Council for Complementary and Integrative Health (NACCIH) held on 06/01/2018. The agenda for this Open Session includes presentations from David Shurtleff, PhD and an interagency panel on the Pediatric Complementary and Integrative Health. For more information on NCCIH and the NACCIH, see https://nccih.nih.gov/about/naccih.
  • NIH VideoCast - NIAID Advisory Council Meeting - June 2018
    • - Dr. Anthony S. Fauci, Director, NIAID, NIH (2018/06/08)
    • - Category : National Institute of Allergy and Infectious Diseases
    Dr. Anthony S. Fauci will address the full Council. Dr. John Mascola will address the full council
  • NIH VideoCast - Division of Microbiology and Infectious Diseases Subcommittee - June 2018
    • - NIAID, NIH (2018/06/08)
    • - Category : National Institute of Allergy and Infectious Diseases
    Report from Division Director and Division Staff
  • NIH VideoCast - Division of Allergy, Immunology and Transplantation Subcommittee - June 2018
    • - NIAID, NIH (2018/06/08)
    • - Category : National Institute of Allergy and Infectious Diseases
    Report from Division Director and Division Staff
  • NIH VideoCast - AIDS Research Advisory Committee - June 2018
    • - Division of AIDS, NIAID, NIH (2018/06/08)
    • - Category : AIDS Research Advisory Committee
    AIDS Research Advisory Committee Meeting - June 2018
  • NIH VideoCast - Festschrift for Frederick L. Ferris III, M.D.
    • - National Eye Institute, NIH (2018/06/08)
    • - Category : Conferences
    A celebration of the career of Frederick (Rick) Ferris III, M.D., former NEI clinical director and director of the NEI Division of Epidemiology and Clinical Applications. Ferris retired in November 2017 after 44 years at the NIH.

    For more information go to https://nei.nih.gov/content/festschrift-frederick-l-ferris-iii-md
  • NIH VideoCast - CC Grand Rounds: 1) Reversing the Tide: Diagnosis and Prevention of Type 2 Diabetes in African Descent Populations and 2) Race/Ethnic Variations in Diabetes Risk Prediction: Insights from Metabolic Studies
    • - 1) Anne Sumner, MD, Senior Investigator, Section on Ethnicity and Health, Diabetes, Endocrinology, and Obesity Branch, NIDDK, NIH and 2) Stephanie Chung, MBBS, Assistant Clinical Investigator, Section on Ethnicity and Health, Diabetes, Endocrinology and Obesity Branch, NIDDK, NIH (2018/06/08)
    • - Category : Clinical Center Grand Rounds
    CC Grand Rounds: 1) Reversing the Tide: Diagnosis and Prevention of Type 2 Diabetes in African Descent Populations and 2) Race/Ethnic Variations in Diabetes Risk Prediction: Insights from Metabolic Studies

    For more information go to http://www.cc.nih.gov/about/news/grcurrent.html
  • NIH VideoCast - Understanding Molecular Signatures of Aging
    • - GR Scott Budinger, MD., Chief, Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine (2018/06/08)
    • - Category : Geroscience
    The Trans-NIH GeroScience Interest Group (GSIG), cordially invites you to its spring seminar, featuring Dr. GR Scott Budinger. Dr. Budinger is the Chief of Pulmonary and Critical Care in the Department of Medicine at Northwestern University Feinberg School of Medicine and is the Ernest S. Bazley Professor of Airway Diseases and a Professor of Medicine (Pulmonary and Critical Care) and of Cell and Molecular Biology. The Budinger laboratory is interested in understanding how aging biology intersects with the age-related risk of acute and chronic lung diseases. The Budinger lab is testing whether a decline in the function of the proteostasis network happens in the lung, and whether this loss of ???proteostasis reserve??? underlies the increased susceptibility to pneumonia, and the increased risk of lung fibrosis and emphysema observed in older individuals. Dr. Budinger???s work is important for our understanding of many diseases in pulmonary and critical care medicine, but importantly is at the forefront of geroscience research because the findings have significant impact on the aging of other organ systems in the body.

    The GSIG was created to discuss and explore the complex relationships between the biology of aging and the biology of diseases and conditions that are of interest to various institutes and centers across the NIH.

    For more information go to https://oir.nih.gov/sigs/geroscience-interest-group-gsig
  • NIH VideoCast - NLM Informatics and Data Science Lecture Series: Semantic Annotations, Reuse, and Reproducibility
    • - Dr. John Gennari, Graduate Program Director, University of Washington (2018/06/08)
    • - Category : Special
    NLM Informatics and Data Science Lecture Series

    Biomodeling (or biosimulation modeling) has the potential to revolutionize patient-specific health care and precision medicine. To increase our knowledge and management of complex pathologies, biomodeling provides the ability to produce detailed, mechanistic simulations of the dynamic biological processes and their participants. The development of these biomodels can be viewed as analogous to software development. To be effective and to scale to larger systems, the models must include clear documentation (semantic annotations), be developed in a reproducible manner, and be designed to allow for plug-and-play reuse so that researchers can build from the efforts of others. In the presentation, Dr. Gennari will report on his group???s efforts to standardize practices for semantic annotation, and to demonstrate the value of those annotations both for semantic searching over model repositories and for model merging and model reuse tasks. Over the last several years, they have succeeded in building community-wide agreement on both the importance of semantic annotation and the format of these annotations. In addition, using their annotation and model reuse tool, they have developed several demonstration examples of model merging that leverage the use of semantic annotation. Finally, as an important consequence of their work, he will also report on the initiation of a new Center for Reproducible Biomedical Modeling. Brief Bio: John Gennari has been a professor in biomedical and health informatics at the University of Washington for over 15 years. His doctorate and background is in computer science, but he began working in biomedical informatics in the early ???90s, beginning with work on the Prot??g?? knowledge representation and ontology development system. He has had a wide range of experiences on large, multi-institutional, multi-disciplinary projects, and this led to his research focus of knowledge reuse and knowledge sharing. His expertise is in ontology development, standards and semantic web tools. Dr. Gennari is the Graduate Program Director at UW, overseeing the PhD and research M.S. programs. He is currently on the NLM Biomedical Informatics, Library and Data Sciences Review Committee.
  • NIH VideoCast - Regulatory T cell differentiation and function
    • - Alexander (Sasha) Rudensky, Ph.D., Chair, Immunology Program, SKI; Director, Ludwig Center, Memorial Sloan Kettering (2018/06/08)
    • - Category : Immunology
    Immunonology IG Seminar

    Dr. Rudensky???s research is focused on understanding the molecular mechanisms governing the differentiation and function of CD4 T lymphocytes and their role in immunity and tolerance. Major areas of interest include: the molecular and cellular mechanisms governing the differentiation and function of regulatory T cells; the roles these cells play in control of autoimmunity, tumor immunity, and immunity to infections, and in the maintenance of immune homeostasis at environmental interfaces. We are particularly interested in understanding the role of the forkhead family transcription factor Foxp3 in establishing and maintaining immune homeostasis; and in the plasticity of regulatory T cell transcriptional and functional programs and the molecular mechanisms of regulatory T cell lineage stability.
  • NIH VideoCast - Causal mechanisms of cortical plasticity and task irrelevant perceptual learning in monkeys
    • - Wim Vanduffel, Ph.D., Harvard Medical School (2018/06/07)
    • - Category : Neuroscience
    NIH Neuroscience Series Seminar

    Dr. Vanduffel has extensive expertise in the use of neuroimaging to study humans and behaving monkeys. His specific area of interest is the primate visual system. He compares directly the functional organization of the visual system in human and non-human primates using the fMRI technique. Currently, he studies how visual representations are modified by extra-retinal signals such as attention and reward and he focuses on functional interactions across brain regions. To achieve this, he is using state-of-the art functional imaging methods combined with behavioral and ???perturb-andmeasurement??? techniques in non-human primates. In particular, he investigates the behavioral and functional consequences of reversible (in)activations using microstimulation, focal drug injections, and genetic-based tools. He also studies the effect of attention and reward signals on sensory processing. For more information go to https://neuroscience.nih.gov/neuroseries/Home.aspx
  • NIH VideoCast - NIH Big Read ???I Contain Multitudes"
    • - Ed Yong, Author and Science Journalist and Dr. Francis Collins, Director, NIH (2018/06/07)
    • - Category : Special
    Author and science journalist Ed Yong visits NIH to discuss his book ???I Contain Multitudes??? with NIH Director Dr. Francis Collins in Masur Auditorium. This presentation is the final event of the NIH Big Read 2018, a collaborative program presented by the NIH Library and the Foundation for Advanced Education in the Sciences (FAES). The NIH Big Read 2018 began with a series of book discussions about ???I Contain Multitudes??? and concludes with this special presentation by the author.

    The discussion will be presented in an interview format with Mr. Yong and Dr. Collins speaking about the world of microbes that exist within and around us. They will explore how microbes influence our daily lives and discuss their potential impact on the future of biomedical research. During the event, Mr. Yong will answer questions from NIH staff.

    The NIH Big Read is intended to foster collaboration and community across NIH through the discussion about a single book over several months, culminating in a special event featuring the author of the book. The program was inspired by the National Endowment for the Arts (NEA) Big Read program and is being presented at NIH by the NIH Library, the Foundation for Advanced Education in the Sciences (FAES), and the Office of the Director (OD).

    For more information go to https://www.nihlibrary.nih.gov/nih-big-read